Antithyroid Drugs, Review NEJM 2005

Antithyroid drugs, which have been in use for more than half a century, remain cornerstones in the management of hyperthyroidism, especially for patients with Graves' disease. Surveys of thyroidologists from the early 1990s indicate that most practitioners consider antithyroid drugs the treatment of choice for most young people with Graves' disease, both in the United States and in the rest of the world.1,2 A substantial amount of new information, much of it evidence-based,3 has become available since the topic was last summarized in the Journal in 1984.4 The present review considers recent pharmacologic and clinical data related to the use . . . Authorized only