Showing posts with label Hemotology. Show all posts
Showing posts with label Hemotology. Show all posts

Friday, January 1, 2010

Management of Sepsis NEJM 2006

A better understanding of the inflammatory, procoagulant, and immunosuppressive aspects of sepsis has contributed to rational therapeutic plans from which several important themes emerge. First, rapid diagnosis (within the first 6 hours) and expeditious treatment are critical, since early, goaldirected therapy can be very effective. Second, multiple approaches are necessary in the treatment of sepsis. Third, it is important to select patients for each given therapy with great care, because the efficacy of treatment — as well as the likelihood and type of adverse results — will vary, depending on the patient... Autorized only

Wednesday, December 30, 2009

Anemia in the Elderly - October 1, 2000 - American Family Physician

Anemia in the Elderly - October 1, 2000 - American Family Physician

DIC, Current Concept, NEJM, 1999

DISSEMINATED intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels. Intravascular coagulation can also compromise the blood supply to organs and, in conjunction with hemodynamic
and metabolic derangements, may contribute to the failure of multiple organs. At the same time, the use and subsequent depletion of platelets and coagulation proteins resulting from the ongoing coagulation may induce severe bleeding (Fig. 1). Bleeding may be the presenting symptom in a patient with disseminated intravascular coagulation, a factor that can complicate decisions about treatment... Authorized only