"Itopride, by virtue of its dopamine D2 receptor antagonism, removes the inhibitory effects on Ach release. It also inhibits the enzyme AchE which prevents the degradation of ACh (8,10) The net effect is an increase in ACh concentration, which in turn, promotes gastric motility, increases the lower esophageal sphincter pressure, accelerates gastric emptying and improves gastro-duodenal coordination."
"Itopride, by virtue of its dopamine D2 receptor
ReplyDeleteantagonism, removes the inhibitory effects on Ach
release. It also inhibits the enzyme AchE which prevents
the degradation of ACh (8,10) The net effect is an
increase in ACh concentration, which in turn, promotes
gastric motility, increases the lower esophageal sphincter
pressure, accelerates gastric emptying and improves
gastro-duodenal coordination."