Management of Sepsis NEJM 2006

A better understanding of the inflammatory, procoagulant, and immunosuppressive aspects of sepsis has contributed to rational therapeutic plans from which several important themes emerge. First, rapid diagnosis (within the first 6 hours) and expeditious treatment are critical, since early, goaldirected therapy can be very effective. Second, multiple approaches are necessary in the treatment of sepsis. Third, it is important to select patients for each given therapy with great care, because the efficacy of treatment — as well as the likelihood and type of adverse results — will vary, depending on the patient... Autorized only